Group I
Montpellier qualified for the quarter-finals as first in group I.
GOG secure a play-off spot if:
- Win or tie against Fraikin BM. Granollers
 
- Lose against Granollers AND HC Kriens-Luzern lose
 
HC Kriens-Luzern secure play-off spot if:
- Win or tie against Montpellier HB
 
- Lose against Montpellier AND Fraikin BM. Granollers lose
 
Fraikin BM. Granollers secure play-off spot if:
- Win against GOG
 
- Tie against GOG AND HC Kriens-Luzern lose
 
In the case Fraikin BM. Granollers beat GOG and HC Kriens-Luzern ties against Montpellier HB, so the following three-team-direct-encounter table would be applied to rank the respective teams.
(Table with results as of main round, round 3)
| 
 Team 
 | 
 W 
 | 
 D 
 | 
 L 
 | 
 Goals 
 | 
 Difference 
 | 
 Points 
 | 
| 
 HC Kriens-Luzern 
 | 
 2 
 | 
 0 
 | 
 2 
 | 
 140 
 | 
 142 
 | 
 -2 
 | 
 4 
 | 
| 
 Fraikin BM. Granollers 
 | 
 1 
 | 
 1 
 | 
 1 
 | 
 109 
 | 
 108 
 | 
 +1 
 | 
 3 
 | 
| 
 GOG 
 | 
 1 
 | 
 1 
 | 
 1 
 | 
 105 
 | 
 104 
 | 
 +1 
 | 
 3 
 | 
Group II
Bidasoa Irun qualified for the quarter-finals as first in group II.
Limoges Handball will finish 2nd and secure play-offs.
Sport Lisboa e Benfica will finish 3rd and secure play-offs.
Ystads IF HF will finish 4th.
Group III
THW Kiel will finish 1st in group III if:
- Win or tie against MT Melsungen
 
MT Melsungen will finish 1st in group III if:
FC Porto will finish 3rd in group III if:
- Win or tie against Vojvodina
 
Vojvodina will finish 3rd in group III if:
Group IV
SG Flensburg-Handewitt, VfL Gummersbach and FENIX Toulouse have secured their play-off spots.
SG Flensburg-Handewitt finishes 1st in group IV if:
- Win or tie against VfL Gummersbach
 
- Lose against VfL Gummersbach by no more than 5 goals AND FENIX Toulouse does not win
 
VfL Gummersbach finishes 1st in group IV if:
- Win against SG Flensburg-Handewitt AND FENIX Toulouse win
 
- Win against SG Flensburg-Handewitt by 6 goals or more AND FENIX Toulouse does not win
 
FENIX Toulouse cannot finish 1st.
If VfL Gummersbach win against SG Flensburg-Handewitt and FENIX Toulouse win against MOL Tatabanya KC, the following three-team-direct-encounter-table would be applied to rank the respective teams:
(Table with results as of main round, round 3)
| 
 Team 
 | 
 W 
 | 
 D 
 | 
 L 
 | 
 Goals 
 | 
 Difference 
 | 
 Points 
 | 
| 
 SG Flensburg-Handewitt  
 | 
 1 
 | 
 2 
 | 
 0 
 | 
 105 
 | 
 100 
 | 
 +5 
 | 
 4 
 | 
| 
 FENIX Toulouse 
 | 
 1 
 | 
 2 
 | 
 1 
 | 
 126 
 | 
 132 
 | 
 -6 
 | 
 4 
 | 
| 
 VfL Gummersbach 
 | 
 1 
 | 
 0 
 | 
 2 
 | 
 94 
 | 
 93 
 | 
 +1 
 | 
 2 
 |