Defending title holders Flensburg drew 33:33 with SAH - Aarhus in the second leg, but a 38:32 win away in the first was enough to secure the German team a 71:65 victory on aggregate.
Elverum Håndball beat Montpellier 35:31, but a devastating 12-goal loss in the first leg, 36:24, meant the win was far from enough to overcome the deficit. Montpellier cruised back to the EHF European League quarter-finals with an aggregate win of 67:59.
In the other two cases, including the highlight match of the week, the second leg was the key. 2024/25 semi-finalists MT Melsungen were fighting a clear deficit against Fredericia Håndboldklub — one they overcame with a 35:26 victory that meant a 64:61 result in their favour on aggregate.
RK Nexe and IFK Kristianstad had played the closest match of the first leg: 36:34 for Nexe. The second leg saw the Croatian side take a 32:27 win for a 68:61 result on aggregate.
THW Kiel, FC Porto, HC Vardar 1961 and Recken - TSV Hannover-Burgdorf qualified directly for the quarter-finals as group winners in the main round.
Quarter-finals (28 April / 5 May):
- RK Nexe vs THW Kiel
- MT Melsungen vs FC Porto
- Montpellier Handball vs HC Vardar 1961
- SG Flensburg-Handewitt vs Recken - TSV Hannover-Burgdorf