Battles to make major breakthrough in Aalborg and Brest
Like PSG and Barca, THW Kiel and Veszprém are the big favourites to progress from the play-offs after their clear away victories in the first leg.
It is a much tighter affair in Poland as Kielce hope to defend their narrow lead at home to Nantes.
Hard-fought first legs mean Aalborg vs Porto and Brest vs Motor are too close to call as all four teams hunt their first trip to the quarter-finals.
MOTW: Aalborg Håndbold (DEN) vs FC Porto (POR)
Wednesday 7 April, 18:45 CEST, live on EHFTV
First leg: 29:32
- Porto won the first leg on home soil, 32:29
 - Aalborg won three of their six home games this season in the Champions League – defeating Zagreb, Nantes and HC Motor
 - on the other hand, Porto's only victory in six away games in the group phase was against Elverum (38:31)
 - Aalborg beat Holstebro 34:30 last weekend in the Danish league, while Porto had no game scheduled
 - the winner of this tie will play against Flensburg or Zagreb in the quarter-finals
 
THW Kiel (GER) vs MOL-Pick Szeged (HUN) 
Wednesday 7 April, 18:45 CEST, live on EHFTV
First leg: 33:28
- Kiel's 33:28 victory in the first leg was not only a huge step towards the quarter-finals, but also their first win at Szeged since 2011
 - Kiel have eliminated Szeged in the knockout stage three times: in the 2014/15 quarter-finals and Last 16 in 2015/16 and 2017/18
 - Kiel have won all four previous home matches against Szeged by at least seven goals – the overall head-to-read record is six victories for Kiel and three for Szeged
 - Szeged’s Joan Cañellas and new arrival Marko Vujin previously played for Kiel
 - both sides are ranked second in their domestic leagues; Kiel are one point below Flensburg in Germany, while Szeged are nine points below Veszprém in Hungary
 - the winners will face PSG or Celje in the quarter-finals
 
Lomza Vive Kielce (POR) vs HBC Nantes (FRA)
Wednesday 7 April, 20:45 CEST, live on EHFTV
First leg: 25:24
- with six goals, Alex Dujshebaev top-scored in the Polish side's precious 25:24 win in France in the first leg
 - in all competitions, only one team has won in Kielce this season: SG Flensburg Handewitt, who won 31:28 in the last round of the group phase
 - Nantes have won three and lost three away games in this season's Champions League
 - Nantes' game against Saint-Raphaël in the domestic league last weekend was postponed
 - Kielce had no domestic game scheduled last weekend
 
SG Flensburg-Handewitt (GER) vs HC PPD Zagreb (CRO)
The matches have been called off. Further information can be found here.
Telekom Veszprém HC (HUN) vs HC Vardar 1961 (MKD)
Thursday 8 April, 18:45 CEST, live on EHFTV
First leg: 41:27
- Veszprém’s 41:27 victory in the first leg at Skopje was the biggest win in the Last 16 since Kielce’s 41:17 victory against Rhein-Neckar Löwen in 2018
 - this result was also Veszprém's biggest victory against Vardar and their ninth win in 12 matches against the North Macedonian side
 - five current Veszprém players have previously played for Vardar: Vuko Borozan, Dejan Manaskov, Jorge Maqueda, Rogerio Moraes and Daniil Shishkarev
 - Vardar wings Timur Dibirov (64 goals) and Ivan Cupic (60 goals) are among the EHF Champions League Men's top 12 scorers, while Petar Nenadic (57 goals) is Veszprém’s top scorer
 - if no miracle occurs, after five years and two Champions League trophies, Croatian right wing Ivan Cupic will play his last European game in a Vardar shirt before he returns to Zagreb
 - Veszprém lead the Hungarian league after 18 victories and one draw
 - the winners of this duel will face Nantes or Kielce
 
HC Meshkov Brest (BLR) vs HC Motor (UKR)
Thursday 8 April, 18:45 CEST, live on EHFTV
First leg: 30:32
- the winners of this tie on Thursday will make history: they will clinch their first ever quarter-final berth in the EHF Champions League
 - Motor's 32:30 victory in Ukraine was their first against Meshkov in the EHF Champions League after two defeats
 - Meshkov only lost once at home in the group phase – against group winners Flensburg – but they beat teams such as PSG and Kielce
 - on the other hand, Motor proved their away strength with victories at Nantes, Celje and Zagreb
 - four Belarusian players in the Motor squad will play on home soil on Thursday: Maxim Babichev, Biachaslau Bokhan, Barys Pukhouski and goalkeeper Ivan Moroz
 - Bokhan (70 goals) is currently the third best scorer in the competition; Brest right wing Mikita Vailupau (67 goals) is ranked fourth
 - the aggregate winners will face Barcelona or Elverum in the quarter-finals
 
Paris Saint-Germain Handball (FRA) vs RK Celje Pivovarna Laško (SLO)
Thursday 8 April, 20:45 CEST, live on EHFTV
First leg: 37:24
- PSG's 37:24 win in the first leg was their biggest victory in an EHF Champions League knockout match
 - Dylan Nahi set a new personal record in the Champions League in that game, scoring 10 goals
 - in all competitions, only one team has beaten PSG at home this season: SG Flensburg-Handewitt, who won 29:28 in round 1 of the group phase
 - the French side easily won against Chambéry in their domestic game last weekend (34:23); Celje's league game was postponed
 - it was made official last week that Celje’s Matic Groselj will be playing in France next season, as he has signed a contract with Chartres